I-Aminoglycosides ihlanganisa iqembu lama-antibiotics elibhekiswe ngesakhiwo esifanayo, isimiso sesenzo kanye nesilinganiso esiphakeme sobuthi. Aminoglycoside amalungiselelo anempahla ecacile ye-antimicrobial futhi ayasebenza ngokumelene nama-Gram-positive ne-Gram-negative bacteria.
Ukuhlukaniswa kwama-aminoglycosides
Kuncike emkhakheni wesicelo kanye nemvamisa yentuthuko yokumelana, izizukulwane ezine zezidakamizwa zabelwe. Ake sicabangele izici eziyisisekelo futhi sizophumela ohlwini lwamagama amalungiselelo-aminoglycosides.
Imithi Yesizukulwane Sokuqala
Lezi yizi:
- Neomycin;
- Streptocin;
- Monomycin;
- I-Kanazin.
Zisetshenziswa ekwelapheni ngokumelene nezifo ezifuywayo zesifo sofuba kanye namanye amabhaktheriya atypical. Ngokumelene ne-staphylococci kanye nama-bacteria amaningi-gram-negative, izidakamizwa azizinamandla. Manje basebenzise cishe.
Aminoglycosides yesizukulwane sesibili
Ummeleli weqembu lesibili lama-antibiotics-aminoglycosides yi-Gentamicin, esebenza kakhulu kuneqembu langaphambilini lemithi.
Isizukulwane sesithathu se-aminoglycosides
Inqwaba yethonya lesizukulwane sesithathu ifana neGentamycin, kodwa isebenza kahle ngokumelene ne-enterobacter, klebiciella ne- Pseudomonas aeruginosa . Leli qembu lifaka:
- Sisomycin;
- I-Tobramycin;
- Amicacin.
Isizukulwane sesine
Leli qembu lihlanganisa i-antibiotic i-Izepamycin, okungezelela ukuthi ikwazi ukulwa ne-nocardia, i-cytobacter, i-aeromonas.
Imiphumela emibi ye-aminoglycosides
Phakathi nenkathi yokwelashwa nale mithi, isiguli singase sibhekane nenani lezinto ezingathandeki. Impendulo eyinhloko yezidakamizwa ubuthi. Kubonakala kulezi zibonakaliso ezilandelayo:
- I-Ototoxicity, eholela ekwehliseni ubukhulu bokuzwa, ukubonakala komsindo ezindlebeni, umuzwa wokuzizwa.
- Umthelela we-Nephrotoxic, izimpawu zazo omile, ushintsho ngobuningi bomchamo, ukunciphisa ukuhlunga kwe-glomerular.
- Ukuwohloka kokuhlanganiswa kokunyakaza nokuzizwa kahle, okuyisici esivela kubantu asebekhulile.
- Ezingxenyeni zesimiso sezinzwa, ukuphazamiseka emlonyeni, ukunganaki, ubuthakathaka, ikhanda lokukhwabanisa, ama-twitchings aguquguqukayo, kubhekwe ukulala.
- Ukubonakala kwezimpawu zokuvimbela i-neuromuscular, kubonakala ekubuyeni kwemisebenzi yokuphefumula kuze kufike ekukhubazekeni okuphethwe imisipha yokuphefumula, kwandisa ingozi ngokulawulwa okufanayo kwe-antibiotics-aminoglycosides nge- relaxant muscle kanye ne-anesthetics, kanye nokumpontshelwa kwegazi eligculisiwe.
Izibonakaliso zokuphendula okweqile azivamile.