I-metaplasia enesigqabhezana (squamous) iyinguquko engewona umdlavuza epithelium yezitho zangaphakathi, okuyisenzo sokuzivikela somzimba esithinta izici ezingathandeki. I-Metaplasia iyindlela yokugulisa umzimba lapho i-epylium eyodwa, ene-prismatic noma i-cubic epithelium ithathwa khona yi-cells eqina kakhulu ye-planar epithelium enamaplanethi amaningi, noma ngaphandle kwama-keratinization. Ngokuvamile kaningi i-metaplasia yamangqamuzana iyathinta i-epithelium yamaphaphu (ikakhulukazi ababhemayo) nomlomo wesibeletho, kodwa futhi ingathinta i-mucosa yesibindi, amathumbu, izigulane zangaphakathi.
Indlela ye-metaplasia yama-squamous cell
Ukuthuthukiswa kwe-metaplasia, sicabanga ngesibonelo somlomo wesibeletho, lapho ukushintshwa kwe-epithelium yesikhuni kuyigugu. I-epithelium ye-metaplastic flat does not develop from the cell cells, but from the underlying, the so-called reserve cells. Okungukuthi, ngaphansi koqweqwe lwe-epithelium eyindilinga, kuhlanganiswa ukwenziwa kwamaseli okugcina, okukhula kancane kancane. Kancane kancane, ingqimba engenhla ye-epithelium ye-cylindrical ihlutshiwe futhi ishintshelwa khona. Okulandelayo kulandela isiteji se-squamous cell metaplasia, lapho izifundo zayo zibonisa ngokucacile imingcele yamaqembu ama-cell storage futhi zakha izingqimba eziningana zamangqamuzana afana ne-epithelium ejwayelekile ye-flat non-coronary.
Esigabeni sokukhula kwe-squamous cell metaplasia, amangqamuzana aphindaphindiwe afana namaseli aphakathi kwe-epithelium flat, futhi esiteji semetaplasia evuthiwe, i-epithelium ayifani nhlobo ne-ecithelium ye-flat flat.
Ingabe i-metaplasia yama-squamous iyingozi?
I-Metaplasia ayisona isifo, kodwa ukuhluka kwesimo semvelo kuyavumelana nezimo ezicindezelayo zomzimba noma ze-pathological. Ngokuqondene nalesi sici esithile, i-squamous cell metaplasia ayitholakali futhi ifundwa kuphela ekufundweni kwelabhutrikhi, ngenxa yokutholakala kwamangqamuzana e-epithelium flat ku-smears, i-sputum, enye impahla yokucwaninga noma ukuhlolwa kwezingcuba zakhe.
Ngokuvamile, i-metaplasia yakhiwa ngokumelene nesimo senqubo yokuvuvukala okungapheli, kanye nemiphumela yangaphandle embi (ukubhema, ukusebenza endaweni engalungile, njll). Nakuba ngokwayo kuyindlela enobungozi, eguquguqukayo, kodwa ukuphikelela isikhathi eside kwezinto ezimbi noma ukungabikho kokwelashwa kwesifo okwenze izinguquko, kungase kuqhubekele phambili ku-dysplasia nesimo esinqunyiwe.
Izimbangela kanye nokwelashwa kwe-metaplasia egcwala
Okuvamile kakhulu i-metaplasia yama-squamous yomlomo wesibeletho. Kungaba ukusabela ku:
- inqubo yokuvuvukala engapheli;
- ukuguguleka komlomo wesibeletho ;
- ukuphazamiseka kwe-hormonal;
- izifo ezithathelwanayo.
I-squamous cell lung metaplasia ivame ukubangelwa ukubhema, kodwa futhi ingabangela izifo ezingapheli (i-bronchitis, i- asthma , njll). I-metaplasia yesibindi ibangelwa izinqubo zokuvuvukala, futhi okokuqala phakathi kwezimbangela yi-cystitis.
Njengoba i-squamous cell metaplasia ihlukile ekuphenduleni komzimba, akudingi ukwelashwa okuqondile. Ngemuva kokuphulukisa isifo esiwumgogodla noma ukuphela komthelela emzimbeni wokucindezeleka, emva kwesikhathi i-epithelium ngokwayo ibuyele evamile. Isibonelo, ukuphatha i-squamous cell metaplasia ye-epithelium ye-bronchial, ecasulwa ngokubhema, kwanele ukushiya lo mkhuba, kanti konke okunye ukwelashwa kuzoba uphawu.