Kuyaziwa ukuthi abantu abane-hypertension isikhathi eside basengozini enkulu yokuhlukunyezwa kwe-myocardial, isifo, ukuguqulwa ezitsheni ze-fundus nokuhluleka okungenangqondo kwe-renal. Ngakho-ke, iziguli ezinokunyuka okuqhubekayo emzimbeni wegazi, zibonisa ukusetshenziswa kwezidakamizwa ezinamandla. Ngokwezifundo zemitholampilo, esinye sezidakamizwa eziphumelele kakhulu futhi eziphephile zengcindezi yiziphilisi zikaLizinopril.
Izinkomba zokusetshenziswa kwamaphilisi e-Lizinopril
Isidakamizwa sinconywa kula macala alandelayo:
- I-hypertension ye-arterial (njenge-ejenti yokwelapha ozimele noma inhlanganisela nezinye izidakamizwa ezishisayo);
- ukuhluleka kwenhliziyo engapheli (ekwelapheni okuhlangene kweziguli ezithatha i-glycosides yenhliziyo nezidakamizwa);
- i-infarction eyingozi ye-myocardial (ukwelashwa kwasekuqaleni ngosuku lokuqala ezigulini ezinemigomo ehleliwe ye-hemodynamic ukugcina le mingcele, kanye nokuvimbela ukungasebenzi kwe-ventricular kwesokunxele nokuhluleka kwenhliziyo);
- i-nephropathy yesifo sikashukela (ukwehla kwe-albinuria ezigulini ezine-type 1 zesifo sikashukela ezivame ukucindezeleka kwegazi kanye neziguli ezine-type II yesifo sikashukela esinomfutho wegazi ophakeme).
Ukwakhiwa kanye nesenzo semithi ye-lisinopril
Into esebenzayo yesidakamizwa yenza i-lisinopril dihydrate. Izinto ezisizayo: i-lactose, isitashi, i-silicon dioxide colloid, i-talc, i-magnesium stearate, njll. U-Lizinopril ukhishwa emafilbheni angu-5, 10 no-20 mg.
Isidakamizwa singokwezigaba ze-inhibitors ye-enzyme yokuguqula i-angiotensin (i-ACE inhibitors). Inikeza i-cardioprotective (ilungisa isimo sokusebenza se-myocardium), i-vasodilator kanye ne-natriuretic (isusa isobho sosawoti nomchamo).
Isilinganiso se-lisinopril
Ngokwemiyalelo yokusetshenziswa, amaphilisi e-lisinopril athathwa kanye ngosuku, kungakhathaliseki ukudla kokudla. Kunconywa ukuthatha lesi sidakamizwa ngesikhathi esifanayo (mhlawumbe ekuseni).
Isilinganiso sincike ekutheni uhlobo lwe-pathology futhi lunganqunywa ngabanye odokotela abaya khona. Ngakho-ke, nge-hypertension ye-arterial, umthamo wokuqala wansuku zonke, njengokubusa, u-10 mg, kanti umthamo wokulondoloza ungama-20 mg. Isilinganiso esiphakeme ngosuku ngalunye akufanele sidlule 40 mg. Uma ukuthatha i-Lisinopril esenzweni esiphezulu akunikezi umphumela oyifunayo, kungenzeka ukuba ubeke imithi eyengeziwe.
Ukuqapha
Ukungafani kokusetshenziswa kwe-lisinopril:
- i-edema idiopathic ifa, i-edema kaQuincke ;
- angioedema emlandweni;
- ukukhulelwa kanye nokulahlwa;
- ukubekezelelana ngabanye izingxenye zezidakamizwa.
Ngokuqapha, lesi sidakamizwa sinqunywe kula macala alandelayo:
- ischemic isifo senhliziyo;
- ukungakwazi ukusebenza komzimba;
- izifo ze-cerebrovascular;
- ama-collagenoses (kufaka phakathi i-systemic lupus erythematosus, i-scleroderma);
- i-hyperkalemia noma ingozi ekhulayo yokutholakala kwayo (ngesifo sikashukela, ukusetshenziswa ngesikhathi esisodwa kwezidakamizwa, ukwehluleka okukhulu kwezinso);
- hyponatremia noma imingcele ye-sodium ekudleni;
- i-hyperuricemia;
- ukufakelwa kabusha kwezinso;
- ukuguga, njll.
Imiphumela emibi ye-lisinopril:
- ikhanda, isizungu;
- ukuphazamiseka kokulala;
- i-tachycardia;
- i-arrhythmia yenhliziyo;
- i-hypotension;
- ukunciphisa i-hemoglobin ne-hematocrit;
- ukukhwehlela;
- isicanucanu, ukuhlanza;
- isifo sohudo;
- umsebenzi wokuqamba umonakalo;
- ukuqhuma kwesikhumba, njll
Ngesikhatsi ukwelashwa nge-lisinopril kufanele njalo kuqaphe ukusebenza kombindi, i-potassium namanye ama-electrolyte e-serum yegazi, igazi lomtholampilo.