Igazi lomuntu liqukethe izinhlobo eziningana zamaprotheni, okumele kube ngesilinganiso esithile sokwenza imisebenzi yabo. Enye yazo i-fibrinogen, inani elinqunywe ekuvivinyweni kwegazi okujwayelekile lokuqedwa. Uma imiphumela ye-fibrinogen ingaphezulu kunejwayelekile, kusho ukuthini, kubalulekile ukuthola.
I-Fibrinogen - iyini?
Eqinisweni, yini i-fibrinogen, iziguli eziningi zinesithakazelo lapho zibona imiphumela ye-coagulogram - isifundo se-laboratory segazi elimnyama, okuvumela umuntu ukuba ahlole ikhono lakhe lokugcoba. Ngokuvamile, lokhu kuhlaziywa kunqunywe ngaphambi kokungenelela okuhlukahlukene kokuhlinzwa, ngesikhathi sokukhulelwa, ngokusola ngezifo ezithile (isibindi, inhliziyo, isimiso semisipha, njll).
Amaphrotheni fibrinogen akhiqizwa izicubu zesibindi futhi, ukungena egazini, lijikeleza lapho esimweni esingasebenzi esingasebenzi. Kungenye yezici zokugaya igazi. Ngenxa yesistimu eyinkimbinkimbi yokusabela ekuphenduleni imiphumela ebuhlungu, isitsha esithintekile sivaliwe nge-clot esima ukuphuma kwegazi. Isisekelo sokwakheka kwe-clot (thrombus) i-fibrin amaprotheni engenayo, etholakala ngokuhlukanisa i-fibrinogen nge-thrombin enzyme.
Ngaphezu kokubamba iqhaza ekusungulweni kwe-thrombus, i-fibrinogen ikhuthaza ukwakheka kwama-vesicles amasha nokuxhumana kwamaselula, futhi ibonisa nezinqubo zokuvuvukala. Ukunciphisa izinga laso kubangele ukuwohloka kwegazi, okubangela ukuphuma kwegazi isikhathi eside, kanye ne-fibrinogen ephezulu kuholela ekwakheni okungavamile kwe-thrombi ngisho ngaphandle kokulimala ezindongeni zamasongo.
Ukunqunywa kwe-fibrinogen
E-laboratories, i-fibrinogen egazini iyalinganiswa ngamasu e-biochemical. Ukuze ugweme amaphutha, lezi zimo ezilandelayo kufanele zigcinwe ngaphambi kwesampula:
- ukudluliselwa kosuku lokutadisha uma kunezibonakaliso zezifo ze-catarrhal;
- ukukhipha ukudla, ukuphuza ikhofi, itiye, iziphuzo ezidakayo 12 amahora ngaphambi kwenqubo;
- ukuqedwa kokuphathwa kwamakhemikhali ekhemikhali okwenza igazi legazi, izinsuku ezimbalwa ngaphambi kokucwaninga (njengoba kuqondiswa udokotela);
- ukunciphisa umzimba, ukushaywa ngokomzwelo ngaphambi kokuhlaziywa;
- ukwenqaba ukubhema okungenani amahora ambalwa;
- Ukuthatha ingilazi yamanzi ahlanzekile engxenyeni yehora ngaphambi kokuthatha igazi.
I-Fibrinogen egazini - okuvamile kubantu besifazane
I-fibrinogen egazini, okujwayelekile okususelwa eminyakeni yobudala bomuntu, kufanele igcinwe ngesamba esingu-2-4 g / l kumama omdala asempilweni, nasemadodeni. Ezinganeni, la mazinga aphansi. Uma, ngokusho kwemiphumela yokuhlaziywa kwe-fibrinogen, isimiso esivela kwabesifazane sibonakala, lokhu kusho ukuthi le protheyini yenziwe ngokwanele, amakhono okuvala igazi awaphuli.
I-Fibrinogen ekukhutheni ivamile
I-Fibrinogen, okuyinto evamile yayo engazinzile kubantu abanempilo, ishintsha indlela yayo evamile uma owesifazane ethwala umntwana. Lokhu kungenxa yokwakhiwa komzimba womama wesistimu entsha yokujikeleza, okufaka i-placenta. Ekuqaleni, izinga lale phrotheni aliningi kakhulu, kodwa ekugcineni kwekota, i-fibrinogen yabesifazane abakhulelwe iyafinyelela phezulu, okudingekayo ukuvimbela ukulahlekelwa kwegazi okukhulu ngesikhathi sokubeletha. Izinkomba zimi kanje:
- I trimester - 2,5-5 g / l;
- II trimester - 2.5-5.1 g / l;
- III trimester - 3.7-6.1 g / l.
I-Fibrinogen yanda - itho ukuthini?
Uma ukuhlaziywa kubonisa ukuthi i-fibrinogen iphakeme kuneyesijwayelekile, kusho ukuthi isiguli sinomthelela omkhulu we-thrombosis-ukutholakala komgwaqo we-vascular okuvinjelwe ukunikezelwa kwegazi kwesigungu esithile noma ingxenye yomzimba. Lesi simo sisongela ukuthuthukiswa kwesifo senhliziyo, i-myocardial infarction, isisindo, isb. i-pathologies eyingozi kakhulu.
Ngezinye izikhathi i-fibrinogen inganda kancane noma okwesikhashana yizici ezilandelayo:
- ukuya esikhathini;
- ukungenela kokusebenza kwangaphambilini;
- ukushisa okwakamuva, ezinye ukuhlukunyezwa;
- izinga lokushisa elincane.
Ngaphezu kwalokho, i-fibrinogen iphakeme kunaleyo evamile kwabesifazane abasebenzisa izidakamizwa ezine-estrogen. Okubi kakhulu kunezimo lapho i-fibrinogen yesikhathi eside iphakeme kakhulu kunokujwayelekile, futhi lokhu kusho ukuthi ukuvuvukala noma ezinye izinqubo ze-pathological zenzeka emzimbeni. Izimbangela eziyinhloko yizi:
- izifo ezivuvukala nezifo ezithathelwanayo zendawo ehlukile (isifo sofuba, pyelonephritis, pancreatitis, njll);
- i-neoplasms eyingozi;
- izinhlobo ezimbi ze- hypothyroidism ;
- ukufa okukhulu kwezicubu (i-pancreatic necrosis, i- abscess yamaphaphu , i-gangrene, njll);
- izifo ezithathelwana ngokuzenzakalelayo esigabeni esisebenzayo (isifo samathambo esiyingozi);
- umonakalo emithonjeni yomzimba (isifo sofuba sikashukela, ukungakwazi ukuphefumula okungavamile, imithi ye-varicose, njll);
- i-thrombohemorrhagic syndrome (isigaba sokuqala);
- i-amyloid dystrophy, njll.
I-Fibrinogen iphakanyisiwe ekukhupheni
Uma i-fibrinogen ngesikhathi sokukhulelwa ihamba ngaphezu komkhawulo ongaphezulu, izimbangela zingase zifane. Lesi simo asongela impilo kanye nokuphila komama ozayo, kodwa futhi sengozini yokukhulelwa. Imiphumela ingaba kanje:
- ukuphumula okungahambi kahle;
- ukuphazamiseka kwamapayipi;
- i-thrombosis ye-cord umbilical;
- ukuzalwa ngaphambi kwesikhathi, njll fibrinogen ngenhla evamile ukuthi lokhu kusho fibrinogen ngaphezu kwesijwayelekile aaa kusho ukuthini
I-Fibrinogen yanda - yini okufanele yenze?
Ezimweni lapho kutholakala ukwanda kwe-fibrinogen, kuyadingeka ukuqhuba izivivinyo ezengeziwe ukuze kunqunywe isici se-causative. Kuphela emva kwalokhu kungathathwa yisikimu sokwelapha, okuhlose ukulungisa isifo esiyisisekelo. Ukuze kunciphise okuphuthumayo inani lale phrotheni, imithi evela eqenjini lama- antiplatelet agents , fibrinolytics, ama-anticoagulants angakunqunywa, ukudla nokunciphisa ukungenisa kwe-cholesterol, ukuzivocavoca nsuku zonke, kunconywa ukubusa okwanele.