Ekuvuvukala nge-pathogen noma izifo ezixubekile (izifo ezincane, isikhunta), izidakamizwa ezinomsebenzi obanzi kakhulu kunokwenzeka. I-5-NOC i-antibacterial agent eyinkimbinkimbi esebenza ngokumelene nama-microorganisms amaningi aziwayo. Kusebenza ngokumelene nama-mycoses ambalwa.
5-NOC - ukwakheka
Isithako esiyinhloko salesi sidakamizwa esibuzwayo yi-nitroxoline. I-composite yamakhemikhali etholakala ku-8-hydroxyquinoline, ivimbela ukuhlanganiswa kwe-DNA kusuka kwamangqamuzana e-pathogenic futhi ivimbela ukukhiqizwa kwayo. Izingxenye ezisizayo ezifakwe ku-5-NOC-tablet ukwakha zihlanganisa:
- i-lactose monohydrate;
- i-calcium hydrogen phosphate;
- isitashi sommbila;
- I-Povidone K25;
- i-colloidal silicon dioxide;
- i-talc ehlanzekile;
- i-magnesium stearate;
- crospovidone.
Amaphilisi akhiqizwa egobolondo elivikelayo, eliqukethe izinto ezilandelayo:
- i-carmellose sodium;
- i-acacia gom;
- i-colloidal silicon dioxide;
- I-Povidone K25;
- i-titanium dioxide;
- isitashi sommbila;
- i-sucrose;
- i-talc ehlanzekile;
- i-calcium carbonate;
- imibala yokudla - ophuzi "i-Sunset Sunset" (E110) ne-quinoline (E104).
5-NOC - inkomba
Lesi sidakamizwa senzelwe ukwelashwa kwezifo eziphuthumayo noma eziphuthumayo zezinhlelo zokuvuthwa nokuzala. Amathebulethi 5-NOC asebenza kahle ngokumelene namaqembu ezincane ezincane:
- I-aerobic ne-anaerobic ye-Gram-positive;
- i-aerobic ne-anaerobic yegram;
- i-mycoplasma ;
- ureaplasma ;
- I-Trichomonas;
- I-Mycobacterium isifo sofuba;
- i-dermatophytes;
- isikhunta isikhunta;
- ukhetho;
- izifo ezihlasela ama-mycoses ajulile futhi aqinile.
5-NOC - izinkomba zokusetshenziswa:
- i-cystitis;
- i-pyelonephritis ;
- i-epididymitis;
- i-urethritis;
- isifo sofuba (adenoma, carcinoma) se-prostate;
- i-prostatitis;
- izinqubo zokuvuvukala kulesi sambatho noma ipheshana eliphumayo.
Ukulungiswa okuchazweyo kusetshenziselwa ukuvimbela ukutheleleka ezimweni ezinjalo:
- isikhathi sokuphoqelela;
- ukuphathwa kokuxilonga;
- i-cystoscopy ;
- i-catheterization.
5-NOC - imiphumela emibi
Imithi eqinile ye-antibacterial ingabangela ukungahambi kahle komzimba kunoma iyiphi indlela. Lokhu kusho ukuthi akavami ukuholela emibikweni. Ezimweni ezihlukile, ukulungiselela oku-5-NOC kubangela:
- i-tachycardia;
- ukuhlanza;
- i-anorexia;
- isicasuli;
- umsebenzi wesibindi okhubazekile;
- isiyezi;
- I-optic neuritis (enezikhathi eside);
- i-paresthesia;
- ukungabi nokusebenzisana;
- ikhanda;
- i-polyneuropathy;
- i-thrombocytopenia;
- ukwanda okukhulu kwe-uric acid;
- i-urticaria;
- ukushaya isikhumba;
- i-ataxia;
- ekhombisa umchamo ngombala ophuzi ophuzi.
5-NOC contraindications
Leli thuluzi alinconywa ukubekezelelana ngabanye kunoma yiziphi izithako ezibalwe ngenhla, kufaka phakathi izinsiza zamakhemikhali ezisizayo kanye nezingxenye zegobolondo. Isidakamizwa esingu-5-NOC sinqatshelwe ngaphansi kwezimo ezinjalo:
- ukukhulelwa;
- i-cataract;
- ukuncelisa;
- ukuphazamiseka okukhulu kwesibindi noma izinso ezinegunya lokudala elingaphansi kuka-20 ml / min (eliqashiwe ngokungajwayelekile, ngokuqapha);
- uneminyaka engaba ngu-3.
Ungathatha kanjani amaphilisi angu-5-NOC?
Ingxenye ejwayelekile yansuku zonke yemithi incike ekutheni iminyaka kanye nobukhona bezinye izifo ezingelapheki. Abantu abadala ngosuku badinga 400 mg yesidakamizwa 5-NOC - uhlelo lokusebenza luhilela ukuthatha leli dose, lihlukaniswe izikhathi ezine, 100 mg (amaphilisi amabili) ngaphambi kokudla. Ngesifo se-bacteria esinamandla, isabelo siphindwe kabili (800 mg). Izingane ezineminyaka engaphezu kwengu-5 ubudala zinqunywe u-200-400 mg wemithi njalo ngamahora angu-24, kanti izingane ezineminyaka engu-3-5 ubudala - 200 mg. Inkambo yokwelashwa jikelele ayidluli kwamasonto amabili kuya ku-4, uma kunesidingo, ukuphinda uyiphinde.
Nge-insufficiency ye-renal ne-hepatic, i-5-NOC isetshenziselwa ukuqapha okukhulu - izinkomba zokusetshenziswa azifaki lezi zifo, kodwa ngezifo ezinzima, i-antibiotic ingabekwa. Kulezi zimo, thatha i-tablet 1 izikhathi ezine ngosuku. Kubalulekile ukuqapha njalo ukusabela kwezinso nesibindi ekwelapheni bese kuqapha izinga lokuvunyelwa kwe-creatinine.
5-NOC - isicelo se-cystitis
Umthamo we-agent elwa namagciwane ahambisana nomthamo ojwayelekile we-400 mg nitroxoline njalo ngamahora angu-24. I-5-NOC nge-cystitis inconywa ngezinsuku ezingu-10-21. Isikhathi esiqondile sokwelashwa kubalwa ngudokotela we-urologist esekelwe ekuhlolweni kwebholabhuthi, ukuqina komsebenzi wokuvuvukala, nokutholakala kwemiphumela emibi ekwelapheni. Ngesinye isikhathi kumele ludluliselwe enyangeni eyodwa, ikakhulukazi uma ukutheleleka kuhlanganisiwe noma kusekondari.
5-NOC nge-pyelonephritis
Ukugula okuchazwe ngesimo esibucayi kudinga inkambo emifushane yokwelapha okulwa nama-antibiotic, 400 mg nsuku zonke amasonto angu-2-2.5. Esikhathini esingapheli se-pyelonephritis ephindaphindiwe, i-urologist inquma ukuthi ithatha kanjani i-5-NOC. Kunezinhlelo zokwelapha okude okwesikhashana (izinyanga ezingu-2-3 izinsuku ezingu-14) kanye nokuhlukahluka okusetshenziswe isikhathi eside kwesidakamizwa kwisilinganiso esincane (100-200 mg).
Ngezinye izikhathi kuthatha isamukeli eside kunazo zonke ze-5-NOC - izinkomba zokusetshenziswa zifaka izinhlobo ezimbi ze-pyelonephritis:
- xanthogranulomatous;
- i-purulent;
- izibalo.
5-NOC ekukhulelweni
Phakathi nesikhathi sokubeletha, isimiso somugogodla wesifazane sisengozini kakhulu futhi sithinteka ezinkambisweni zokuvuvukala. Ngenxa yalokhu, omama abalindayo kaningi banesithakazelo ku-5-NOC - ngingayiphuza ngesikhathi sokukhulelwa nokuthi yimiphi imingcele. Le mithi ye-antibiotic iyaphikisana nalesi simo, ngoba ingaphazamisa ukuthuthukiswa noma ukwakheka kwe-fetus.
Okufanayo 5-NOC
Lapho umuthi olwa namagciwane we-antimicrobial ungeke usetshenziswe noma ubangela imiphumela emibi kakhulu, kuyodingeka ikhanseliwe. Indlela kuphela yokufaka amaphilisi e-5-NOC ngokusebenzisa izivumelanisa ezifanayo noma ezijwayelekile. Kunezifanekiselo ezimbili eziqondile kumuthi ochazwe:
- I-nitroxoline (eJalimane, eRussia);
- Uroksolin (Ukraine).
Isidakamizwa sokuqala sikhiqizwa ngokuhlushwa okuhlukile kwesithako esisebenzayo, esilungele ukwelapha ngemithi ephakeme. Ikhambi lesibili kuphela kumathebulethi anomkhiqizo osebenzayo wamakhemikhali ka-50 mg. Uma ukungahambisani ne-nitroxoline noma okutholakala kwayo kutholakala, kuyadingeka ukusebenzisa uhlobo. Lesi sidakamizwa sinezici ezifanayo ezifanayo ne-5-NOC - izinkomba eziyinhloko zokusetshenziswa, umsebenzi we-antibacterial and antifungal, kodwa ukwakheka okuhlukile. Imithi ephumelelayo inikezwa ngesimo se-bacteriophages:
- i-dysentery polyvalent;
- izintambo;
- uma;
- i-staphylococcal;
- Amaprotheni;
- I-Klebsiella pneumonia;
- I-Pseudomonas (i-pseudomonas);
- kolik-proteyny;
- i-salmonella.
Amanye ama-generic anezinkomba ezifanayo:
- I-Fosmicin;
- Ureacid;
- I-Fosmural;
- UBernie;
- I-Fosmicin;
- Isiyingi;
- I-Phosphoral;
- Urophosfabol;
- I-Cystoral;
- I-Forterase;
- Urofoscin;
- I-phosphocin;
- Espa-Focine.