Inkathi yokulungiselela ukukhulelwa okuzayo komama ozayo ihlotshaniswa nezifundo eziningi. Phakathi kwabo, nokuhlaziywa kweso sakhi njenge-homocysteine. Cabanga ngalokhu okuningiliziwe ngokuningiliziwe, sizokuthola ukuthi kungani homocysteine inqunywa ekuhleleni kokukhulelwa, yiziphi izinkomba zendabuko nokuthi yini eholela ekwandeni nasekunciphiseni.
I-Homocysteine - yenzani ngabesifazane?
Uma uthumela owesifazane ekuhlaziyweni, okuyinto enquma izinga lika-homocysteine egazini, yiluphi uhlobo locwaningo oluningi labamama abazayo abakwaziyo. Lesi sici umkhiqizo wokucubungula i-methionine (i-amino acid). Izinga lika-homocysteine egazini likhula kancane kancane uma likhulelwa, kodwa lapho likhulelwa, ukuhlushwa kwalo kunciphisa (1 no 3rd trimesters).
I-Homocysteine ekuhleleni ukukhulelwa kubalulekile ukuhlola ngenxa yethonya layo elibi ekusebenzeni kokubeletha. Phakathi nalesi sikhathi, lokhu kusebenza kunomthelela oqondile ekuhambeni kwe-placental, lapho ukuthuthukiswa kwangaphakathi kwe-intrauterine kwe-fetus nesivinini sayo kuxhomeke khona. Odokotela bacabanga ukuthi kuyadingeka ukubeka ukuhlushwa kwe-homocysteine esiteji sokulungiselela ukukhulelwa okuzayo ukuze uphendule ngesikhathi sokunciphisa noma ukwanda, futhi uthathe izinyathelo.
Yini i-homocysteine ebonisa?
Ukufunda ukuthi yini i-homocysteine, ama-moms angaba khona emgodini wokulungiselela ukukhulelwa acele odokotela umbuzo - ukuthi ukuhlaziywa kwenziwe ngani, futhi kubonisani. Ngokusekelwe emiphumeleni, odokotela benza iziphetho mayelana nezinqubo ze-intracellular emzimbeni wesifazane. Ngakho-ke, uma ukugaya umzimba kwe-homocysteine kuphazamiseka, kuhlanganiswa isikhala se-extracellular, bese ku-plasma yegazi. Ezingxenyeni eziphakeme, le nhlanganisela inomphumela we-cytotoxic.
Ngenxa yenkambiso enjalo, kungase kube nokuphulwa kobuqotho bezindonga zemikhumbi - ubuso babo bube bukhululekile. Endaweni yezindawo ezilimazekile, i-calcium ne-cholesterol zihlala phezu kwemikhumbi. Ngenxa yezinguquko ezinjalo, ukwakheka kwephakethi ye- atherosclerotic kwenzeka. Lokhu kwandisa ingozi yamakhemikhali egazi emithanjeni yegazi, ehambisana nokuthuthukiswa kwe-thrombosis ngesikhathi sokukhulelwa.
Kungani kufanele uthathe i-homocysteine ngenkathi uhlela ukukhulelwa?
Izinga lika-homocysteine egazini livumela odokotela ukuba bafinyelele iziphetho mayelana nezinqubo ze-intracellular. Ukwephulwa komzimba wayo kwandisa ingozi yegazi emithanjeni yegazi. Lolu shintsho lugcwele ukuvinjelwa kwemivimbo ese-placenta. Ngenxa yalokho, kukhona ukwephulwa kwentuthuko yengane ngesikhathi sokukhulelwa. Ukuyivimbela, odokotela bazama ukukhomba izifo kanye nokuzikhethela kuso ngesikhathi sokuhlela.
Ucwaningo lwe-Homocysteine lokuhlela ukukhulelwa
Ukunquma izinga le-homocysteine ekuhleleni ukukhulelwa, odokotela babhekisela abesifazane ekuhlaziyweni. Kulolu daba, odokotela batusa ukuba bangene kulezi zivivinyo izinyanga ezintathu ngaphambi kokuqala kokuhlela. Uma umama wesikhathi esizayo wayekade enezinkinga ngesifo somzimba emzimbeni we-homocysteine, isifundo senziwa kungakapheli izinyanga eziyisithupha ngaphambi kosuku olulindelekile lokukhulelwa.
Homocysteine - ukulungiselela
Ukuze uhlaziye i-homocysteine ngenkathi uhlela ukukhulelwa, kubalulekile ukugcina imithetho eminingana ngesikhathi sokulungiselela. Ukwenza lokhu:
- Ngolunye usuku ngaphambi kwesikhathi sokwembula kwegazi, kubalulekile ukukhipha ukudla okunamafutha nokuphuza utshwala ekudleni.
- Ngosuku olulandelayo ngaphambi kokutadisha, imisebenzi yemvelo enamandla ayinqatshelwe.
- Amahora angu-8-14 ngaphambi kokulinganisa isampula segazi akuvunyelwe ukuthatha ukudla, ukuphuza kuphela (okulula, namanje amanzi) kuvunyelwe.
- Ungapheli imizuzu engu-30 ngaphambi kokuhlolwa.
Homocysteine - ukuthatha kanjani?
Ngaphambi kokuthatha u-homocysteine ngenkathi ehlela ukukhulelwa, owesifazane uthola ukudluliselwa kudokotela. Isifundo ngokwayo senziwa ekuseni ngesisu esingenalutho. Ukuhlaziywa kwenziwa ngokuthatha isampula yegazi kusuka emithanjeni ye-ulnar. Ukunquma i-homocysteine ekuhleleni kokukhulelwa kokuqala, u-2-5 ml wegazi uthathwa, obekwe embotheni oyinyumba, ebhalwe phansi futhi athunyelwa ebhokisithri. Imiphumela ingatholakala ezinsukwini ezingu-2-3, ngokuya ngomsebenzi osebenzayo esikhungweni sezokwelapha.
I-Homocysteine - evamile kubafazi lapho behlela ukukhulelwa
Isilinganiso se-homocysteine lapho uhlela ukukhulelwa ngu-10-11 μmol / l. Lokhu kuhlushwa kuthathwa njengendlela evamile yokuphila. Ukuphambuka kubonisa ukwephula, futhi kudinga ukuqaliswa kwezinyathelo zokulungisa. I-algorithm yokuqaliswa kwayo iqhutshwa ngabanye, ngokucabangela isimo jikelele somzimba wesifazane, ukutholakala kwezifo ezingapheliyo kanye nezinqubo ze-pathological. Ukuhambisana nezincomo zezokwelapha ezitholiwe nemigomo, kusiza ekuqedeni ukuphulwa okusheshayo, i-homocysteine elungile, okujwayelekile okukhonjisiwe ngenhla.
I-homocysteine ephakeme ekuhleleni ukukhulelwa
Ngokuvamile ukuhlushwa okwandisiwe kwe-homocysteine kubangelwa ukungajwayelekile lapho ukhulelwe. Ngenxa yalokhu, ukulungiswa kufanele kwenziwe ngesikhathi sokuhlela. Ngaphambi kokunciphisa i-homocysteine, odokotela benza ukuhlolwa okuphelele okuhloswe ekuqaliseni imbangela yokwanda. Inqubo yokwelapha i-homocysteine ithuthukiswa ngokucabangela isifo se-pathological:
- Ukunciphisa izinga lamavithamini B. Kulesi simo, odokotela banquma ukudla ngokuqukethwe okuphezulu kwe-thiamine, i-pyridoxine, i-folic acid.
- Umphumela we-nicotine. Kutholakale ukuthi ukubhema kubangela ukwanda kwezinga le-homocysteine. Ukunciphisa udinga ukuyeka i-nicotine .
- I-caffeine. Uma uphuza ikhofi, ukuhlushwa kwe-homocysteine kwanda. Ukuze unciphise, udinga ukukhipha isiphuzo.
- Izinga eliphansi lomsebenzi womzimba. Ukuzivivinya okusebenzayo kusiza ukunciphisa i-homocysteine.
I-homocysteine yehla uma uhlela ukukhulelwa
Ukuqonda indlela yokunciphisa i-homocysteine ekukhuliseni ukuhlela, kufanele kuthiwe ukuthi isimo esihlukile sibheke - ukuntuleka kwayo. Uma i-homocysteine iyancipha kancane, lokhu akunakwenzeka nganoma iyiphi indlela inqubo yokuzala umntwana. Ukukhathazeka kufanelekile ukujezisa lapho i-homocysteine ephansi kakhulu ibhalwa - 4.1 μmol / l futhi iphansi. Ezimweni ezinjalo, odokotela banikeza ukwelashwa okhethekile ukwandisa izinga lempahla. Umama ozoba khona naye angathatha izinyathelo zokuqinisekisa ukuthi izinga lika-homocysteine lilinganisani:
- Ukunciphisa umsebenzi omkhulu wokuzivocavoca - ukukhipha isikhathi esithile ukuqeqeshwa kwezemidlalo nsuku zonke.
- Ukuphuza ikhofi ekuseni.