Imithi ye-Cordarone nayo yonke imibonakaliso yayo kanye nokuphikisana okuyoyisebenzisayo kungokwalabo beqembu lezidakamizwa ezithathelwanayo zesigaba sesithathu. Okusho ukuthi, isenzo saso sisekelwe ekuvinjweni kweziteshi ze-potassium. Isidakamizwa sinempahla ye-antiarrhymics yesigaba sokuqala nesine. Futhi ngokufanayo, ingakwazi ukuvimba imigudu ye-sodium ne-calcium kanyekanye. Phakathi kwezinye izinto, lesi sidakamizwa sinokuvimbela i-beta-adrenergic, imiphumela ephikisana ne-anti-anginal kanye ne-coronary.
Izinkomba zokusebenzisa amaphilisi eKordaron
Isisekelo semithi yi-amiodarone hydrochloride. Umthamo ojwayelekile wezithako ezisebenzayo ngu-200 mg. Ngaphezu kwalokho, ukwakheka kokulungiselela kufaka phakathi izingxenye ezinjalo ezisizayo:
- i-anhydrous colloidal silicon dioxide;
- i-lactose monohydrate;
- i-magnesium stearate;
- isitashi sommbila;
- I-Povidone.
I-Cordarone yezidakamizwa iboniswa ukusetshenziswa kokubili ukwelashwa nezinhloso ze-prophylactic. Yenza njalo ku:
- ama-tachycardias angaphezu kwe-paroxysmal;
- i-arrhythmias ye-ventricular;
- i-Wolff-Parkinson-White syndrome;
- i- extrasystole engaphezulu kanye neyomhlaba ;
- i-flutter ye-atrial;
- i-sinus tachycardia;
- ukutakula ngemuva kokuhlukunyezwa kwe-myocardial;
- isigaba esibucayi se-infarction ye-myocardial;
- i-fibrillation ye-atrial;
- ukwephulwa kwemisebenzi ye-ventricle;
- ischemic isifo senhliziyo;
- ukuhlasela kuka-angina pectoris .
Indlela yokusebenzisa amaphilisi e-Kordaron anqunywa udokotela oya khona. Izindlela ezahlukene zokwelashwa zingasetshenziswa ekwelapheni. Ngakho-ke, ngokwezilungiselelo zokugula, isilinganiso sokuqala esingu-600-800 mg se-amiodarone hydrochloride, sihlukaniswe ngamanani amaningi. Isilinganiso esiphezulu esivumelekile somthamo wansuku zonke singama-10 g. Futhi lokhu ukwelashwa kuthatha izinsuku ezinhlanu kuya kweziyisishiyagalombili.
Uhlelo lokwelapha iziguli lufana, kodwa kufanele luhlale isikhathi eside - kusukela ezinsukwini eziyishumi kuya kwamasonto amabili. Kubalulekile ukukhumbula ukuthi ubude besikhathi sokuphila kweKordaron akude kakhulu, ngakho-ke kunconywa ukuthi uyisebenzise nsuku zonke. Ungaphinde uphuze amaphilisi ngamancane - kuze kube yizinsuku ezimbalwa - iziphazamiso.
Qala ukwelapha bonke ochwepheshe batusa ngesilinganiso esincane futhi ugxile emthonjeni wokwelashwa ophumela. Uma lesi siphetho singanele, khona-ke umthamo kufanele wanda.
Ukungafani kokusetshenziswa kwe-Cordarone
Ukuqhathaniswa cishe kunoma imuphi umuthi. Futhi uCordaron kwakungenjalo. Akunconywa ukuba aphathwe nalesi sidakamizwa sokulwa uma:
- ukucabangela ukucubungula kwizingxenye zokubunjwa;
- Ukwandiswa kwesikhathi se-QT (kokubili kokuzalwa nokutholwa);
- i-sinus bradycardia;
- ukuvinjelwa kwe-sinoatrial;
- ukukhulelwa;
- ukuncelisa;
- isifo samaphaphu emaphakathi;
- hypokalemia;
- i-hypomagnesemia;
- izidakamizwa ze-thyroid (njenge-hyper- noma hypothyroidism);
- i-atrioventicular ivinjelwe kusukela eyokuqala kuya kwesithathu.
Izingane akufanele ziphuze amaphilisi ngaphambi kokuyishumi nesishiyagalombili. Ngokuqapha okukhulu, i-Cordarone kufanele ihanjiswe iziguli ezine:
- i-hypotension ye-arterial;
- ukwehluleka kwenhliziyo noma ukuhluleka kwenhliziyo okungapheliyo;
- ukuphazamiseka kwengqondo;
- i-asthma ye-bronchial;
- i-cardiomyopathy;
- ukungakwazi ukusebenza kahle.
Thatha imithi ngaphansi kokuqondiswa kwengcweti, kanye neziguli ezisebekhulile umzimba wazo obuthakathaka yizinguquko ezihlobene nobudala futhi zivezwe engozini.
Kuyinto engathandeki kakhulu ukuhlanganisa i-Cordarone nemithi enjalo:
- Quinidine;
- Iphutha;
- I-Quinine;
- Pimozide;
- I-Fluphenazine;
- I-Spiramycin;
- I-Misolastine;
- I-Sultopride;
- Terfenadine;
- I-Haloperidol;
- I-Bretilia;
- I-Sotalol;
- I-Spiramycin;
- I-Chlorpromazine;
- I-Ciammazine.