I-17-OH progesterone noma i-17-hydroxyprogesterone iyi-hormone ye-steroid ekhishwa kwi-cortical substance ye-grenal adrenal futhi iyandulela ama-hormone anjenge-cortisol, estradiol kanye ne-testosterone. Iphinde ikhiqizwe ezindlini zobulili, i-follicle evuthiwe, umzimba ophuzi kanye ne-placenta futhi ngaphansi kwethonya le-enzyme 17-20 lyase iphenduka ama-hormone ocansi. Okulandelayo, sizocabangela ukuthi iyiphi i-progesterone engu-17 edlala emzimbeni wesifazane ongakhulelwe futhi ekukhulelwe kanye nezimpawu zokwanda nokwehluleka kwazo.
Izici eziphilayo ze-hormone 17-oh progesterone
Izinga lomuntu ngamunye le-17-OH progesterone lishintsha phakathi kwamahora angu-24. Ngakho-ke, ukuhlushwa kwayo okuphezulu kunqatshelwe emahoreni asekuseni, kanti ubuncane - ebusuku. I-17-OH progesterone yabesifazane ihlukahluka kuye ngesigaba sokujikeleza esikhathini. Ukunyuka okuphezulu kwezinga laleli hormone kuphawulwe ngehora lesikhukhula (ngaphambi kokwanda okwenziwe ukwanda kwe-hormone). I-pro-prote-17-OH e-phase follicular iyanciphisa ngokushesha, ifinyelela ezingeni eliphansi esigabeni sokuvuthwa.
Manje cabanga ngamanani avamile we-17-OH progesterone, kuye ngokuthi isigaba somjikelezo wesimiso:
- esigabeni esilandelayo - 0.99-11.51 nmol / l;
- esigabeni se-follicular - 1,24-8,24 nmol / l;
- esigabeni sokuvuthwa - 0,91-4,24 nmol / l.
I-17-OH progesterone ekukhusheni iyakhula, ifinyelela amanani ayo amakhulu emasontweni amuva nje. Ngesikhathi sokukhulelwa, i-placenta iphinda iphendule ngokuqalwa kwe-hormone ye-steroid. Cabanga ukubaluleka okuvunyelwe kwe-17-OH progesterone ngesikhathi sokukhulelwa:
- ku-trimester yokuqala - 3,55-17,03 nmol / l;
- kwi-trimester yesibili - 3,55-20 nmol / l;
- kwi-trimester yesithathu - 3.75-33.33 i-nmol / l.
Ku-premenopausal nangesikhathi sokuya esikhathini, izinga le- hormone 17-OH progesterone liyehla kakhulu futhi lifinyelela ku-0.39-1.55 i-nmol / l.
Shintsha ezingeni lika-17-OH progesterone - ukuxilongwa nezimpawu
Izinga elinganele le-17-OH progesterone egazini livame ukubangelwa i-hyprélasia engavamile futhi ingahlanganiswa nokukhiqiza okwanele kwamanye ama-hormone. Ngokwemithi, ingabonakalisa ngesimo sesifo se-Addison, futhi abafana bangathuthuki ama-genitalia angaphandle.
Ukwanda kwe-17-OH progesterone kungavamile ukubonwa kuphela ekukhulelwe, kwezinye izimo kubonisa ukugula. Ngakho-ke, i-progesterone ephezulu ka-17-OH ingaba uphawu lwezicubu ezinzima, ama-ovari (ama-formations amahle kanye ne-polycystosis) kanye nezifo zofuzo ze-cortex e-adrenal.
Ngokwemithi, ukwanda kwe-17-OH progesterone kungabonakaliswa:
- ukwephulwa komjikelezo wokuya esikhathini;
- ukungabi namuntu;
- ukukhipha isisu okuzenzekelayo;
- ukubeletha noma ukushona kwasekuseni;
- ukwanda kwe-progesterone 17-OH kungabonakaliswa ngenduna (izibhamu);
- Uma i-pro-progestone engu-17-OH iphakanyisiwe, i-testosterone nayo ingaphakanyiswa. Lokhu kungabonakala ngendlela yokukhula kwezinwele ebusweni nasemzimbeni (uhlobo lwezinwele zesilisa).
Izinga le-17-OH progesterone linganqunywa ngokuhlola i-serum
Ngakho-ke, sihlolisise indima yezinto eziphilayo emzimbeni we-hormone 17-OH progesterone kanye namanani ayo avumelekile kwabesifazane. Ukuncipha kwezinga le-hormone kungavamile ukuphela kokuya esikhathini, kanti ukwanda kwalo kuthathwa njengokujwayelekile phakathi nokukhulelwa. Izinguquko ezingeni lika-17-OH progesterone kwezinye izimo zingase zibe esinye sezibonakaliso zesifo se-adrenal and ovarian, okuholela ku-hyperandrogenism, ukungasebenzi noma ukukhipha isisu okuzenzakalelayo.