Izidakamizwa ze-Antiepileptic yimithi enamandla okuvimbela ukuthuthukiswa kokugubha noma ukunciphisa ubuhlungu babo ezigulini ezixilongwa ngesithuthwane. Benza ngokucindezela ebuchosheni ukuxoshwa ngokweqile kwegazi le-neurons ebuchosheni, lapho kuqale khona ukuhlasela.
Izidakamizwa ze-antiepileptic zisebenza kanjani?
Isimiso esijwayelekile semithi esetshenziselwa ukuthunjwa yisinciphiso esheshayo ekuvuthweni kwe-neuronal. Kodwa zonke izindlela zaleli qembu zibonisa ukuvimbela okukhethiwe komsebenzi wezinzwa ze-pathological. Le mpahla yemithi enjalo ihambisana nokuhlukaniswa kwezidakamizwa zokulwa nezifo. Bangakwazi:
- Ukwandisa umsebenzi we-neurons okuvimbela;
- ukuvimbela ama-excitatory receptors we-neurons;
- kuthinta ngqo ukuziphatha komfutho kagesi.
Imiphumela eminingi emibi evela emva kokuthatha izidakamizwa ze-antiepileptic ayibalulekile. Kungaba ukhathala, inzuzo yesisindo noma isiyezi. Kodwa kwezinye izimo, ukwelashwa kwesithuthwane kuholela ekuthuthukiseni kwengqondo noma ukucindezeleka. Yingakho, uma umuntu esanda kuqala ukuphulukisa isifo sokuphuza, umthamo ulawulwa ukuze izinga eliphephile nelisebenzayo lomuthi lifinyelelwe egazini. Njengomthetho, esigabeni sokuqala sokwelashwa, ukulinganisa okuphansi kunazo zonke kwezidakamizwa kunqunywe, okuyinto enqunywe isigamu sempilo yomuthi.
Iziphi izidakamizwa zokulwa nezifo ezishiwo?
Njengamanje, izidakamizwa eziningi zanamuhla zokulwa nezifo zivunyelwe ukwelashwa kwesithuthwane. Udokotela njalo uncoma umuthi, ngokusekelwe ezicini eziningana:
- Uhlobo lokubanjwa nezifo. Ezinye izidakamizwa ze-antiepileptic zalesi sizukulwane esidala noma esisha zisebenza ngokuphumelelayo ekulawuleni izigameko ezingapheli (isib. Ethosuximide), kuyilapho ezinye zibekiwe kulabo abaye baphuthuma ngokuphindaphindiwe
(Rufinamide noma Diazepam). - Iminyaka yobudala nempilo yesiguli. Iziguli ezinezingane eziphuthumayo noma ezifunda esikoleni ngokuvamile zibizwa ngokuthi i-carbamazepine, i-phenytoin noma i-valproate, futhi labo abaye balwa nalesi sifo bavame ukubeka izidakamizwa ezintsha zokulwa nezifo (Trileptal or Topamax).
- Amathuba okukhulelwa. Kukhona iqembu lezidakamizwa ezenzelwe abesifazane abangakhulelwa. Zivikelekile kakhulu kumntwana okhulayo (i-Carba-mazepine, i-Lamotrigine no-Valproate).