Enye yezinkomba ezibaluleke kunazo zonke, odokotela abayifunde ngokuningiliziwe ngesikhathi sokubeletha owesifazane, yi- fibrinogen . Kuyiprotheni edlala indima enkulu ekusebenzeni kwegazi lokugcoba. I-fibrinogen ikhiqizwa ngamaseli wesibindi, ke, ukungena egazini, ngaphansi kwethonya lokuthinta i-fibrin. Ukuhlaziywa kwegazi kwe fibrinogen, okuyinto evamile yayo ekhonjiswe esibhedlela, kubaluleke kakhulu, kokubili kumama nangomntwana. Kungenxa ye-fibrin leyo fomu ye-thrombi, eyanciphisa ukulahleka kwegazi ngesikhathi sokubeletha.
Umkhuba we-fibrinogen egazini
Umkhuba we-fibrinogen emadodeni enempilo u-2-4 amagremu ngelitha ngalinye. Phakathi nokuthuthukiswa kwe-fetus esibelethweni, zonke izinhlelo zenyama yomama ozayo zinezinguquko eziningi, kanti futhi izinga laleli protheine linencazelo ehlukile. Ngakho-ke, izinga le-fibrinogen ekukhulelwe lifinyelela ku-6 amagremu ngehora elilodwa legazi. Lesi sibonakaliso siqala ukwanda kusuka ezinyangeni ezingaba ngu-3, futhi ekupheleni kokukhulelwa kufinyelela ekuphezulu. Lokhu kungenxa yokuthuthukiswa kwesistimu ye-circulatory ye-utero-placental. Ngaphezu kwalokho, ngesikhathi sokusebenza, kunengozi yokulahlekelwa igazi eliningi, ngakho umzimba uqala ukukhiqiza amaprotheni, okufaka isandla ekusebenzisaneni kwawo.
Ukuze unqume umkhuba we-fibrinogen, owesifazane okhulelwe unikezwa ukuhlolwa kwegazi - i-coagulogram. Ukuhlaziywa kunikezwa ekuseni ngesisu esingenalutho ngokuthatha igazi emunwe noma emithanjeni. Ukuhlaziywa okuningiliziwe okubizwa ngokuthi i-hemostasiogram. Udokotela ukhetha ukuhlaziywa ku-1st, 2nd and 3rd trimester yokukhulelwa. Lesi sibonakaliso singashintsha kancane ngokuya ngesimo jikelele kanye nobude bokukhulelwa. Ngakho, ngo-trimester yokuqala izinga le-fibrinogen lingashintsha kusuka ku-2.3 g kuya ku-5 g, okwesibili - kusuka ku-2.4 g kuya ku-5.1 g, futhi kwesithathu - kusuka ku-3.7 g kuya ku-6.2 g.
I-Fibrinogen - okungavamile kwabesifazane abakhulelwe
Uma kunoma yikuphi ukuphambuka kulesi sibonakaliso, uhlelo lokugaya igazi luphazanyiswa, i-fibrinogen ephansi noma ephakeme ngesikhathi sokukhulelwa idala njalo udokotela ngokukhathazeka okukhulu mayelana nempilo yengane engakazalwa kanye nomphumela ophephile wokusebenza. Uma kwenzeka ukuthi i-fibrinogen iphakeme kunokujwayelekile, kunengozi yezindwangu zegazi ngokweqile emithanjeni yegazi, okungaholela ekuphukeni komsebenzi we-cardiovascular. Ukwanda kwalesi sibonakaliso kungabonisa ukuba khona kwezinqubo zokuvuvukala emzimbeni wesifazane okhulelwe - igciwane, ukutheleleka, noma inqubo yokufa kwezicubu. Lesi simo singagcinwa lapho owesifazane egula ngemfuluwenza, i-ARVI noma i-pneumonia.
Ukuncipha kwinhlawulo kungaholela ekulahlekelweni okukhulu kwegazi ngesikhathi sokubeletha. Isizathu sokuthi i-fibrinogen ekukhutheni iyancipha, kungenzeka ukuthi i-toxicosis ephuzile (gestosis) noma ukungabi namavithamini B12 no-C. Esinye isizathu sokuntuleka kwamaprotheni ukukhiqizwa yi-DIC syndrome. Lesi sifo, esihlobene nokuphulwa kwegazi lokugwedla ngokuphathelene nokukhiqizwa kwenani elikhulu lezinto ze-thromboplastic.
Kunezimo ezinzima nakakhulu lapho i-fibrinogen iphansi kakhulu kunokujwayelekile, okwenza umzimba wesifazane okhulelwe othuthukisa i-hypofibrinogenemia. Lesi sifo singaba sesibhedlela futhi sitholakale. Esikhathini sokuqala, amaprotheni akhiqizwa, kepha awufezi imisebenzi yawo, noma akhiqizwa nhlobo. Ifomu elitholakalayo lesi sifo libhekwa nje lapho ukhulelwe. Kulesi simo, isibonakaliso sinciphise sibe yi-1-1.5 amagremu
Isizathu sokuthuthukiswa kwe-hypofibrinogenemia kumfazi okhulelwe kungaba ukuphazamiseka kwamapayipi, ukufa komntwana kanye nokuhlala kwakhe isikhathi eside esibelethweni, noma ukubandakanya i-amniotic fluid (ithola ngenxa yokungena kwamanzi amniotic egazini likaMama).
Ukuhlaziywa okunquma izinga le-fibrinogen kungenye yezinyathelo ezibalulekile zokubonwa komuntu ngamunye. Le ndlela ikuvumela ukuba ungabandakanyi noma ubone izingozi ezingenzeka zokuthuthukiswa kwe-fetal kanye ne-labor lab. Ngakho-ke, kuyadingeka ukuba uhlale ucwaninga futhi ulandele izincomo zikadokotela wakho.