Naphezu kwenqubekela phambili enkulu yezokwelapha nempumelelo ekuchazeni i-genetic code, i- rheumatoid arthritis isalokhu isifo esinzima kakhulu esingapheli. Lezi zifo zinezimpawu ezizenzekelayo, izimbangela eziqondile zokuthuthukiswa kwazo azikakhiwa. Ngokuphathelene nalokhu, ososayensi baye basungula izikhungo zokucwaninga, bahlakulela ngokuqhubekayo ukwelashwa okuphumelelayo kwe-arthritis ye-rheumatoid - izidakamizwa zesizukulwane esisha esenza ngokushesha kunabo abandulele. Ngaphezu kwalokho, amanxusa anjalo akhuthaza imiphumela emibi emiphakathini, ayibekezelele kangcono.
Ukulungiselela ukwelashwa kwamanje kwesifo samathambo
Ukwelashwa kwesifo esicatshangelwayo kunamaqembu amabili izidakamizwa:
- anti-inflammatory ;
- eziyisisekelo.
Uhlobo lokuqala lwemithi lusetshenziselwa ukuphumula okusheshayo kobuhlungu emalungwini nezinye izibonakaliso zesifo samathambo esifubeni, ukwelashwa okuphawulekayo.
Amalungiselelo ayisisekelo anciphisa ukuqhubekela phambili kwe-pathology noma adlulisele inkambo yawo ibe yisimo sokuxolelwa, eqondisa ngokuqondile izindlela zokuthuthukiswa kwesifo, ukucindezela umsebenzi wesimiso somzimba.
Esikhundleni semithi engaphelele, engabangeli nje imiphumela emibi kakhulu, kodwa futhi yenza kancane kancane (esikhathini esingaphezu kwezinyanga ezimbalwa), ama-biological agents eze. Ukulungiswa kobuchwepheshe bezakhi zofuzo ku-arthritis ye-rheumatoid kuthinta umsebenzi wokuzivikela, okungukuthi - ukucindezela ukukhiqizwa kwamaseli e-cytokine okuvusa izinqubo zokuvuvukala nomonakalo ohlangene ohlangene. Inzuzo enkulu yama-biological agents yikhono labo lokusebenza kuphela eqenjini elilodwa lezinhlaka zomzimba, ngaphandle kokuthinta ezinye izindlela. Ngaphezu kwalokho, imishanguzo enjalo ikuvumela ukuba uthole imiphumela ngokushesha kakhulu kunezidakamizwa ezisetshenziswa ngaphambili, umphumela oveziwe usuvele uvele emavikini angu-2-4 kusukela ekuqaleni kokungeniswa.
Imithi yokwelapha ye-genetic ye-arthritis ye-rheumatoid ibuye ihlanganise nezidakamizwa ezinamakhomikhali e-monoclonal ezikwamukeli eziphezulu ze-B-lymphocyte - amaseli ahilelekile ekusebenziseni ukubhujiswa okuhlanganyelwe kanye nokuthukuthela ukuvuvukala. Eqinisweni, izidakamizwa ezichazwe nazo zivimbela ukukhiqizwa kwama-cytokines, kodwa namanje ezinyathelweni zokuqala, "kuhlumela."
Uhlu lwezidakamizwa ezintsha zokuzala ukwelashwa kwesifo samathambo
Ama-biological agents okukhulunywe ngaso esigabeni esandulele angahle ahlukaniswe ngokomzimba zibe izinhlobo eziningana ngokusho kwesenzo sabo. Namuhla, izidakamizwa ezintsha ezilandelayo zisetshenziselwa ukwelapha isifo samathambo:
1. I-interleukin-1 inhibitors:
- I-Kinneret (anakinra).
2. Izivimbela ze-tumor necrosis factor noma i-TNF-blockers:
- I-Remicade (i-infliximab);
- I-Enbrel (etanercept);
- Humirae (adalimumab).
3. Kusho ukuthi ukuphazamisa umsebenzi we-B-lymphocytes:
- I-Rituxan (rituximab).
4. Imithi ephazamisa ukusetshenziselwa kwamagciwane e-immune T:
- Orence (abatacept).
Okwamanje, yonke imithi ehlongozwayo ikhiqizwa phesheya futhi ayinazo izifaniso.
Ingabe izidakamizwa ezintsha zenzalo ziphumelela ngokumelene ne-arthritis ye-rheumatoid?
Ngokusho kocwaningo lwezokwelapha kanye nokubuyekezwa okuningi kwama-rheumatologists, kanye neziguli zabo, izidakamizwa ezinikeziwe zishesha futhi zenze umphumela omuhle nakwezinye izimo zokulimala ezihlangene. Ucwaningo luye lwabonisa ukuthi owesithathu wabantu abanesifo samathambo e-rheumatoid isifo sokuphulukiswa okuqhubekayo sokugula emva kokusetshenziswa kwama-biological agents.