I-Mifepristone isebenza kanjani uma ukukhulelwa kuphazamiseka?
Esikhathini sokuqala sokukhulelwa, okungukuthi, ngaphambi kwesikhathi sesonto eliyisithupha, lesi sidakamizwa singasetshenziselwa ukuphazamiseka okuphuthumayo noma ukuhlehliswa okuhleliwe. I-Mifepristone ivimbela ukuhlanganiswa kweprogesterone ezingeni lama-receptors, futhi njengoba le hormone iyadingeka ukuze kuqhutshekwe inkambo evamile yokukhulelwa kanye nesisu, ngenxa yamukelwa kwayo, ukulahlwa kweqanda lomntwana wesisu kwenzeka.
Ngakho-ke, ngaphansi kwesenzo somuthi, ama-capillary e-placental abhujiswe, ngenxa yalokho umbungu ufihla ezindongeni zesisu futhi ususwe ngaphandle. Njengomthetho, ukuze kutholakale umphumela osheshayo futhi ophawulekayo, ukwengezwa kwe-prostaglandins, isibonelo, i-Dinoprost noma i-Misoprostol, kunqunywa ngokwengeziwe. Lezi zidakamizwa zandisa ukwenziwa kwesivumelwano somzimba wesisu, ukuze iqanda le-fetal likhuphuke ngokushesha kakhulu.
UMifepristone usebenza kanjani ngesikhathi sokubeletha?
Ngokuvamile, i-mifepristone isetshenziswe ekupheleni kwesikhathi sokukhulelwa ukuze kukhuthazwe ukulethwa uma kwenzeka inqubo yokuzalwa yemvelo ingenzeki kowesifazane. Kulesi simo, ukuthatha lesi sidakamizwa kukhuthaza ukuvulwa komlomo wesibeletho kanye nokuqala kokunyakaza kwe-fetal nge-canal yokuzalwa. Njengomthetho, nge-course evamile yokukhulelwa, lokhu kuholela ekwenzeni ukulwa nokuphunyuka kwe-amniotic fluid, ukuze umama osemncane abelethwe ngokuzalwa.
UMifepristone usebenza ngokushesha kangakanani?
Abaningi besifazane abaphoqeleka ukusebenzisa le mithi banesithakazelo embuzweni wokuthi uMifepristone usebenza kanjani ngokushesha ngesikhathi sokuvuselelwa komsebenzi noma ukuqedwa kokukhulelwa. Lesi sikhathi sincike ezintweni eziningi kanye nesimo jikelele somzimba wentombazana, kodwa ngokwesilinganiso umphumela wokuthatha imithi uqala ukubonakala ngemuva kwamahora angu-24. Ngesikhathi esifanayo, ukuhlushwa okukhulu kwe-Mifepristone egazini lomama ozayo kufinyelelwa emahoreni angu-4. Ukuphila kwengxenye yesidakamizwa, futhi, kuyamahora angu-18.
Kodwa-ke, kukhona amacala lapho, emva kosuku, i-Mifepristone ayinayo ithonya emzimbeni wesifazane okhulelwe, futhi kulokhu kufanele athathe elinye iphilisi. Uma-ke, ukuphathwa kwesikhathi kwesidakamizwa akuzange kube nomphumela oyifunayo, udokotela angase anikeze elinye ikhambi elihle kakhulu.
I-Mifepristone ithinta kanjani ingane?
Ukudla kwe-Mifepristone esilinganisweni esifanele ngokungabikho kokuphikisana komuntu okhulelwe akuthinti kakhulu ingane. Noma kunjalo, le nqubo ingasetshenziselwa ukugqugquzela ukulethwa kuphela ngaphansi kokuqondwa kukadokotela, ngoba imithi embi kakhulu futhi ingabangela izinkinga.
Ukudlula umthamo ovumelekile we-Mifepristone akunakwenzeka kunoma yiziphi izimo - lokhu kungabangela ukuqala kwe-hypoxia yengqondo enganeni engakazalwa, okuyoholela ekutheni kube nemiphumela emibi kuze kube sekufeni komntwana.
Ungamisa kanjani isenzo se-Mifepristone?
Ezimweni ezingavamile, kungase kube khona isimo lapho kuyoba khona isidingo sokumisa isenzo seMifepristone futhi umise ukuphazanyiswa kokukhulelwa. Ukuze wenze lokhu, faka ama-200 mg we-Progesterone nge-intramuscularly ngezinsuku ezimbili ezilandelanayo ngemuva kokuthatha lesi sidakamizwa, bese wenza izijovo ezinjalo izikhathi ezingu-2-3 ngesonto kuze kube sekupheleni kwe-trimester yesibili.
Ukugcina ukukhulelwa kulezi zimo akukhona njalo, futhi amathuba okubeletha ingane ngokuphumelelayo yiyona ephakeme, isikhathi esincane esidlule phakathi kokudla kwe-Mifepristone ne-Progesterone.